John Callahan's QUADS! tells the story of Reilly O'Reilly, a foul mouthed drunk who gets run over by a millionaire and rendered a quadriplegic. The driver of the car, ridden by guilt and fearful of lawsuits, gives Reilly a mansion. Reilly fills the mansion with people "less fortunate than himself" and together the handicapped anti-heroes form a dysfunctional little family.